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Faculty of Biology, Chemistry & Earth Sciences

Höcker lab – Protein Design

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3D-structures (X-ray, NMR & Computational models)

Three-dimensional structures (X-ray crystallography, NMR & Computational models)

CheYHisF Chimeric protein build from fragments of CheY and HisF


Bharat  et al., 2008
HisF-C***C Artificial (ba)8-barrel build from identical halves 2W6R Höcker et al., 2009
HisA-II HisA mutated to perform the reaction of TrpF 2W79 Claren et al., 2009
ABP-stn Arabinose binding protein designed to bind serotonin, but without its ligand 2WRZ Schreier et al., 2009
Eno S39N D321R Enolase with substitution S39N and D321R plus PEP 2XGZ Schreier et al., 2010
Eno S39N Q167K Enolase with substitution S39N, Q167K and D321R plus PEP 2XH0 Schreier et al., 2010
Eno S39N D321A Enolase with substitution S39N and D321A plus 2-PGA 2XH2 Schreier et al., 2010
Eno S39A D321A Enolase with substitution S39A and D321A plus 2-PGA 2XH4 Schreier et al., 2010
Eno D321A Enolase with substitution D321A plus 2-PGA 2XH7 Schreier et al., 2010
PotF_SPD Putrescine binding protein engineered to bind spermidine 4JDF Scheib et al., 2013
N-TM0182 The sequence of N-TM0182 is equally related to two different folds 4Q37 Farias-Rico et al., 2014
de novo TIM-barrel Crystal structure of a designed, four-fold symmetric TIM-barrel protein 5BVL

Huang, Feldmeier et al., 2016

LAO L117K LAO L117K mutant with Glutamin bound 5OWF Banda-Vazquez et al., 2018

NMR Structure

CheYHisF-RM Chimeric protein build from CheY and HisF optimized by computational design 2LLE Eisenbeis et al., 2012

Computational Models

Homology model of the chimera CheYHisF, input for design calculationsmore ...Eisenbeis et al., 2012
CheYHisF-RosettaCheYHisF with mutations suggested by computational design with Rosettamore ...Eisenbeis et al., 2012

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