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Faculty of Biology, Chemistry & Earth Sciences

Höcker lab – Protein Design

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3D-structures (X-ray, NMR & Computational models)

Three-dimensional structures (X-ray crystallography, NMR & Computational models)

CheYHisFChimeric protein build from fragments of CheY and HisFmore ...Bharat  et al., 2008
HisF-C***CArtificial (ba)8-barrel build from identical halvesmore ...Höcker et al., 2009
HisA-IIHisA mutated to perform the reaction of TrpFmore ...Claren et al., 2009
ABP-stnArabinose binding protein designed to bind serotonin, but without its ligandmore ...Schreier et al., 2009
Eno S39N D321REnolase with substitution S39N and D321R plus PEPmore ...Schreier et al., 2010
Eno S39N Q167KEnolase with substitution S39N, Q167K and D321R plus PEPmore ...Schreier et al., 2010
Eno S39N D321AEnolase with substitution S39N and D321A plus 2-PGAmore ...Schreier et al., 2010
Eno S39A D321AEnolase with substitution S39A and D321A plus 2-PGAmore ...Schreier et al., 2010
Eno D321AEnolase with substitution D321A plus 2-PGAmore ...Schreier et al., 2010
PotF_SPDPutrescine binding protein engineered to bind spermidinemore ...Scheib et al., 2013
N-TM0182The sequence of N-TM0182 is equally related to two different foldsmore ...Farias-Rico et al., 2014
de novo TIM-barrel
Crystal structure of a designed, four-fold symmetric TIM-barrel protein

Huang, Feldmeier et al., 2016

NMR Structure

Chimeric protein build from CheY and HisF optimized by computational design
more ...
Eisenbeis et al., 2012

Computational Models

Homology model of the chimera CheYHisF, input for design calculationsmore ...Eisenbeis et al., 2012
CheYHisF-RosettaCheYHisF with mutations suggested by computational design with Rosettamore ...Eisenbeis et al., 2012

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